L-5-Methyltetrahydrofolate Calcium

L-5-Methyltetrahydrofolate Calcium is the active metabolic form of folic acid and belongs to the derivatives of tetrahydrofolate calcium salt.

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L-5-Methyltetrahydrofolate Calcium is the active form of folic acid, which can be directly utilized by the human body and participates in key physiological processes such as DNA synthesis and amino acid metabolism.

L-5-Methyltetrahydrofolate Calcium is mainly used in the formulation of milk powder, solid beverages, etc.

Certificate of Analysis
   Product   Name: L-5-methyltetrahydrofolate calcium Quantity :11.746Kg
   Standard                :USP43 Package :50g/bag
   Batch    Number     :LFC250416014 Production  Date   :Apr.16,2025
   Date of inspection:Apr.21,2025 Expiry Date       :Apr.15,2027
Inspection item Standard provisions Result
1.Appearance White to light yellow crystalline
powder,odorless
Conforms
2.Identification Infrared detection Conforms
Calcium detection Conforms
The retention time of HPLC main
peak was in line with the standard
Conforms
3.Content(on dry basis) 95.0%~102.0% 99.28%
4.Water 6.0%~17.0% 14.30%
5.Calcium(on dry basis) 7.0%~8.5% 8.42%
6.Impurities 4-aminobenzoyl-glutamic acid ≤0.5% 0.08%
4-a-Hydroxy-5-methyltetrahydr
ofolic acid
≤1.0% 0.05%
(6S,R)-Mefox ≤1.0% 0.08%
Tetrahydrofolic acid ≤0.5% 0.18%
7,8-Dihydrofolic acid ≤0.5% Undetected
Folic acid ≤0.5% 0.07%
5,10-methylenetetrahydrofolic

acid
≤0.5% Undetected
5-methyltetrahydrop teroic acid ≤0.5% 0.05%
Dimethylterahydrofolic acid ≤0.15% 0.01%
Total impurities ≤2.5% 0.63%
7.Heavy metals ≤20mg/kg ≤20mg/kg
8.Elemental impurity Plumbum ≤1.0mg/kg ≤1.0mg/kg
Arsenic ≤1.5mg/kg ≤1.5mg/kg
Mercury ≤1.5mg/kg ≤1.5mg/kg
Cadmium ≤0.5mg/kg ≤0.5mg/kg
Boron ≤50mg/kg ≤50mg/kg
Platinum ≤10mg/kg ≤10mg/kg
Chloride ≤0.5% 0.06%
9.Residual solvents(Ethanol) ≤0.5% 0.01%
10.D-5-methyltetrahydrofolic acid ≤1.0% 0.32%
11.Microbial Limits Total aerobic bacteria ≤1000CFU/g Undetected
Total number of mold and yeast ≤100CFU/g Undetected
Salmonella Non-detectable Undetected
Escherichiacoli Non-detectable Undetected
Staphylococcus aureus Non-detectable Undetected
Pseudomonas aeruginosa Non-detectable Undetected
Candida albicans Non-detectable Undetected
Clostridia Non-detectable Undetected

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